1-[2-(2-CHLOROPHENOXY)ETHYL]PIPERAZINE synthesis
- Product Name:1-[2-(2-CHLOROPHENOXY)ETHYL]PIPERAZINE
- CAS Number:20383-85-1
- Molecular formula:C12H17ClN2O
- Molecular Weight:240.73
Yield:-
Reaction Conditions:
with hydrogen bromide in ethanol;water at 20; for 48 h;Reflux;
Steps:
4. General Procedure for the Synthesis of Intermediates 4a-4r
General procedure: HBr (aq. 40%, 0.02 mol and 2.60 mL) was dropwise added to a solution of piperazidine (0.02 mol) in EtOH (50 mL) at r.t., and then 3a-3r (0.01 mol) in EtOH (50 mL) was added. The mixture was refluxed for 48 h, filtered and concentrated. The residue was dissolved in water, acidified with 10% HCl aq. to pH = 5-6 and washed with CH2Cl2, water layer was basified by 10-50 % NaOH till pH > 9 and extracted with CH2Cl2, dried over NaSO4 and evaporated until dryness to obtain the compounds 4a-4r with colorless oil in 35.24-70.98 % yields.
References:
Guo, Xiaoke;Ma, Xianglei;Yang, Qian;Xu, Jing;Huang, Lu;Jia, Jianmin;Shan, Jiaojiao;Liu, Li;Chen, Weilin;Chu, Hongxi;Wei, Jinlian;Zhang, Xiaojin;Sun, Haopeng;Tang, Yiqun;You, Qidong [European Journal of Medicinal Chemistry,2014,vol. 81,p. 89 - 94] Location in patent:supporting information
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20383-85-1
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