1-(2,4-Difluorobenzyl)piperazine 2HCl synthesis
- Product Name:1-(2,4-Difluorobenzyl)piperazine 2HCl
- CAS Number:204013-06-9
- Molecular formula:C11H14F2N2
- Molecular Weight:212.24
Yield:204013-06-9 92%
Reaction Conditions:
in tetrahydrofuran at 70;
Steps:
13 Preparation 13 1-(2,4-difluorobenzyl)piperazine
Preparation 13 1-(2,4-difluorobenzyl)piperazine [0163] A mixture of piperazine (26.5 g, 308 mmol) in THF (350 mL) was heated to 70° C. and 1-(chloromethyl)-2,4-difluorobenzene (5 g, 30.8 mmol) was added. The suspension was heated at 70° C. overnight. The solid (piperazine) was filtered off, and the solvent was removed under reduced pressure. The residue was partitioned between EtOAc and water. The organic layer was dried and concentrated to give the title compound (6 g, 92%). ESI-MS m/z [M+H]+ 213.04
References:
US2015/175602,2015,A1 Location in patent:Paragraph 0163
1065586-31-3
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