![](/CAS/GIF/70931-33-8.gif)
1-[2-(4-Fluorophenyl)ethyl]piperazine synthesis
- Product Name:1-[2-(4-Fluorophenyl)ethyl]piperazine
- CAS Number:70931-33-8
- Molecular formula:C12H17FN2
- Molecular Weight:208.28
![1-Piperazinecarboxylic acid, 4-[2-(4-fluorophenyl)ethyl]-, ethyl ester](/CAS/20210111/GIF/70931-36-1.gif)
70931-36-1
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Yield:-
Reaction Conditions:
with potassium hydroxide in ethanol;water;toluene;
Steps:
17 EXAMPLE 17
37.2 g of 1-ethoxycarbonyl-4-[2-(4-fluorophenyl)ethyl]-piperazine are dissolved in 55 ml of ethanol, and a solution of 47 g of potassium hydroxide in 12.5 ml of water is added dropwise, while stirring. The whole is heated at 115°-120° for 6 hours while stirring, concentrated to dryness by evaporation, taken up in toluene, washed with saturated sodium chloride solution and concentrated to dryness by evaporation under reduced pressure. The 1-[2-(4-fluorophenyl)ethyl]-piperazine which remains behind can be purified via the dihydrochloride which has a melting point of 270°-272°.
References:
US4804661,1989,A
![4-Fluorostyrene](/CAS/GIF/405-99-2.gif)
405-99-2
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![1-(2-BROMOETHYL)-4-FLUOROBENZENE](/CAS/GIF/332-42-3.gif)
332-42-3
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![1-[2-(4-Fluorophenyl)ethyl]piperazine](/CAS/GIF/70931-33-8.gif)
70931-33-8
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