1-[2-(4-Fluorophenyl)ethyl]piperazine synthesis

5synthesis methods

Product Name:1-[2-(4-Fluorophenyl)ethyl]piperazine
CAS Number:70931-33-8
Molecular formula:C12H17FN2
Molecular Weight:208.28

1-Piperazinecarboxylic acid, 4-[2-(4-fluorophenyl)ethyl]-, ethyl ester

70931-36-1
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Yield:-

Reaction Conditions:

with potassium hydroxide in ethanol;water;toluene;

Steps:

17 EXAMPLE 17

37.2 g of 1-ethoxycarbonyl-4-[2-(4-fluorophenyl)ethyl]-piperazine are dissolved in 55 ml of ethanol, and a solution of 47 g of potassium hydroxide in 12.5 ml of water is added dropwise, while stirring. The whole is heated at 115°-120° for 6 hours while stirring, concentrated to dryness by evaporation, taken up in toluene, washed with saturated sodium chloride solution and concentrated to dryness by evaporation under reduced pressure. The 1-[2-(4-fluorophenyl)ethyl]-piperazine which remains behind can be purified via the dihydrochloride which has a melting point of 270°-272°.

References:

US4804661,1989,A

405-99-2 Synthesis