ChemicalBook CAS DataBase List 1,2,4-OXADIAZOLIDINE-3,5-DIONE

1,2,4-OXADIAZOLIDINE-3,5-DIONE synthesis

5synthesis methods

Product Name:1,2,4-OXADIAZOLIDINE-3,5-DIONE
CAS Number:24603-68-7
Molecular formula:C2H2N2O3
Molecular Weight:102.05

350036-98-5
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Yield:24603-68-7 91%

Reaction Conditions:

with acetic acid;sodium nitrite in water at 0 - 5; for 8 h;

Steps:

1.2; 2.2; 3.2

2) Under ice-water bath conditions, add compound 2 (10.1g, 0.1mol), 90mL of deionized water, and 40g of acetic acid into the flask. After the addition is complete, slowly add 9.7g (0.14mol) of sodium nitrite. After the addition is complete, TLC monitors The reaction temperature is 0-5°C, and the reaction time is 8 hours. After the reaction, the reaction solution is placed in a refrigerator overnight, filtered to obtain a yellow solid, and recrystallized with pure water to obtain the target compound 1,2,4-oxadiazole-3, 5-dione, the yield is 91%.

References:

CN113264897,2021,A Location in patent:Paragraph 0035-0037; 0040-0041; 0044-0045; 0048