1-(2,6-difluorophenyl)cyclopropanecarboxylic acid synthesis
- Product Name:1-(2,6-difluorophenyl)cyclopropanecarboxylic acid
- CAS Number:139229-58-6
- Molecular formula:C10H8F2O2
- Molecular Weight:198.17
124276-65-9
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139229-58-6
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Yield:139229-58-6 89%
Reaction Conditions:
with sulfuric acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
Steps:
8 (2,6-Difluorophenyl)-cyclopropanecarboxylic acid STR26
(2,6-Difluorophenyl)-cyclopropanecarboxylic acid STR26 A suspension of 17.9 g (100 mmol) of 1-(2,6-difluorophenyl)-cyclopropylnitrile in a mixture of 60 ml of ice water and 40 ml of concentrated sulfuric acid was refluxed for 4 hours. The mixture was cooled to 25° C., after which the resulting precipitate was separated off, washed with water and dried. Yield=89%; mp.: 150°-153° C.; colorless crystals.
References:
US5371268,1994,A
654-01-3
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$12.00/5g
139229-58-6
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