1-(2-Amino-4-fluoro-5-methoxyphenyl)-1-propanone synthesis

2synthesis methods

Product Name:1-(2-Amino-4-fluoro-5-methoxyphenyl)-1-propanone
CAS Number:124623-37-6
Molecular formula:C10H12FNO2
Molecular Weight:197.21

Preparation by successively adding propionitrile and aluminium chloride to a solution of boron trichloride and 3-fluoro-4-methoxyaniline in benzene under nitrogen and refluxing the mixture obtained for 8 h (70%).

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1-(2-Amino-4-fluoro-5-methoxyphenyl)-1-propanone

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Yield:124623-37-6 15.3 g

Reaction Conditions:

Stage #1: 3-fluoro-4-methoxyaniline;propiononitrilewith aluminum (III) chloride;boron trichloride in n-heptane;dichloromethane; for 3 h;Heating / reflux;
Stage #2: with hydrogenchloride;water for 0.75 h;Heating / reflux;

References:

US6339091,2002,B1 Location in patent:Example 28

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References