1-(2-amino-5-chlorophenyl)propan-1-one synthesis

6synthesis methods

Product Name:1-(2-amino-5-chlorophenyl)propan-1-one
CAS Number:1685-20-7
Molecular formula:C9H10ClNO
Molecular Weight:183.63

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Yield:1685-20-7 91%

Reaction Conditions:

with water;iron;ammonium chloride in ethanol at 90; for 0.5 h;

Steps:

2.b

b) To a mixture of 1-(5-chloro-2-nitrophenyl)propan-1-one (2.49 g, 11.66 mmol) in EtOH (20 mL) and H₂O (10 mL) was added iron powder (3.25 g, 58.28 mmol) and NH₄Cl (312 mg, 5.83 mmol) and the reaction was rapidly stirred at 90° C. for 30 min. The hot reaction mixture was filtered (the residues were washed with EtOAc) and further EtOAc and H₂O added. The EtOAc layer was separated, dried over MgSO₄and concentrated under reduced pressure. The residue was filtered through a pad of silica (eluting with CH₂Cl₂/PE, 7:3) to afford 1-(2-amino-5-chlorophenyl)propan-1-one (1.95 g, 91%), as a yellow solid.

References:

US2007/238700,2007,A1 Location in patent:Page/Page column 27

106-47-8 Synthesis