1-(2-aminothiazol-4-yl)ethanone hydrochloride synthesis
1synthesis methods
- Product Name:1-(2-aminothiazol-4-yl)ethanone hydrochloride
- CAS Number:116008-78-7
- Molecular formula:C5H7ClN2OS
- Molecular Weight:178.6399
Yield:116008-78-7 97%
Reaction Conditions:
in ethanol at 20; for 1 h;
Steps:
1.1b
(1b) To a stirred mixture of thiourea (8.87 g, 115 mmol) in ethanol (20.9 mL) was added 1-chloro-2,3-butanedione (13.90 g, 115 mmol) dropwise, a slight exothermic reaction resulted. The mixture was stirred at ambient temperature for 1 hour. The reaction mixture was filtered and the precipitate washed with ethyl ether (2*). The tan solid was air dried then dried under high vacuum overnight to give 1-(2-amino-thiazol-4-yl)-ethanone hydrochloride as a tan solid (21.5 g, 97%).
References:
US2006/41146,2006,A1 Location in patent:Page/Page column 10