1,2-BIS(PHENYL)-1,1,2,2-TETRAFLUOROETHANE synthesis

11synthesis methods

Product Name:1,2-BIS(PHENYL)-1,1,2,2-TETRAFLUOROETHANE
CAS Number:425-32-1
Molecular formula:C14H10F4
Molecular Weight:254.22

116-14-3
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591-50-4 Synthesis

591-50-4
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(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZENE

5123-13-7
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1,2-BIS(PHENYL)-1,1,2,2-TETRAFLUOROETHANE

425-32-1
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Yield:425-32-1 83%

Reaction Conditions:

with 1,10-Phenanthroline in tetrahydrofuran at 60; under 2660.18 Torr; for 20 h;Inert atmosphere;

Steps:

4.1 Synthesis of 1,1,2,2-tetrafluoro-1,2-diphenylethane

Example 4-1
Synthesis of 1,1,2,2-tetrafluoro-1,2-diphenylethane
CuO^tBu (2.7 mg, 0.02 mmol), 1, 10-phenanthroline (3.6 mg, 0.02 mmol), 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (3.8 mg, 0.02 mmol), iodobenzene (4.9 mg, 0.024 mmol, 1.2 eq), and α,α,α-trifluorotoluene (2.4 μL, 0.02 mmol; as an internal standard for
¹⁹F NMR) were mixed in 0.5 ml of THF/THF-d₈ (v/v'=4/1) solvent in an NMR tube under a nitrogen atmosphere. TFE was pressurized to 3.5 atm, and the mixture was heated at 60° C. for 20 hours. ¹⁹F NMR confirmed the generation of the target product 1,1,2,2-tetrafluoro-1,2-diphenylethane at a yield of 83%.

References:

US2016/214999,2016,A1 Location in patent:Paragraph 0446; 0447; 0448

134-81-6 Synthesis