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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-(2-bromo-5-methoxy-phenyl)ethanone
6342-63-8

1-(2-bromo-5-methoxy-phenyl)ethanone synthesis

12synthesis methods
Obtained by action of pyridinium chlorochromate with 1-(2-bromo-5-methoxy) ethanol.
544-97-8 Synthesis
DIMETHYLZINC

544-97-8
133 suppliers
$150.00/5g

2-BROMO-5-METHOXYBENZOYL CHLORIDE

56658-04-9
41 suppliers
$310.00/50g

1-(2-bromo-5-methoxy-phenyl)ethanone

6342-63-8
61 suppliers
$31.00/250mg

-

Yield:6342-63-8 99%

Reaction Conditions:

in toluene at 0 - 20; for 0.5 h;

Steps:

1; 10

Preparation of 1-(2-bromo-5-methoxy-phenyl)-ethanone (108): EPO [0194] To an ice cold solution of 8.75 g (35 mmol) 2-bromo-5-methoxy-benzoy1 chloride in 40 niL toluene, 9.63 mL (19.25 mmol) of a 2M toluene solution of dimethylzinc was added under argon atmosphere (dimethylzinc is pyrophoric - contact with air should be avoided.). The ice bath was removed and the mixture slowly warmed up to room temperature. Once the reaction starts it proceeds rapidly resulting in a turbid solution. The reaction was complete in 30 minutes. It was then cooled back to 0 °C and was quenched by adding 10 mL ethanol. The mixture was evaporated to dryness, the residue was dissolved in a mixture of 50 mL IM HCl and 100 mL ethyl acetate. The organic phase was separated and washed with 50 mL water (2x), brine (2x) and was dried (Na2SO4). The final solution was evaporated and the oil dried overnight in high vacuum to give 7.96 g (99%) of the title compound as a colorless liquid; 1H-NMR (CDCl3): δ (ppm) 7.46 (d, 1H), 6.96 (d, 1H), 6.83 (dd, 1H), 3.80 (s, 3H), 2.63 (s, 3H).

References:

WO2006/76529,2006,A1 Location in patent:Page/Page column 92; 93-94

Benzenemethanol, 2-bromo-5-methoxy-α-methyl-

71095-23-3
2 suppliers
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1-(2-bromo-5-methoxy-phenyl)ethanone

6342-63-8
61 suppliers
$31.00/250mg

References
586-37-8 Synthesis
3-Methoxyacetophenone

586-37-8
322 suppliers
$10.00/5g

1-(2-bromo-5-methoxy-phenyl)ethanone

6342-63-8
61 suppliers
$31.00/250mg

References
7507-86-0 Synthesis
2-Bromo-5-methoxybenzaldehyde

7507-86-0
188 suppliers
$7.00/1g

1-(2-bromo-5-methoxy-phenyl)ethanone

6342-63-8
61 suppliers
$31.00/250mg

References
676-58-4 Synthesis
Methylmagnesium chloride

676-58-4
291 suppliers
$15.00/25ml

2-BROMO-5-METHOXYBENZOYL CHLORIDE

56658-04-9
41 suppliers
$310.00/50g

1-(2-bromo-5-methoxy-phenyl)ethanone

6342-63-8
61 suppliers
$31.00/250mg

References