1-(2-Bromophenylsulfonyl)-2-methylpiperidine, 97% synthesis
- Product Name:1-(2-Bromophenylsulfonyl)-2-methylpiperidine, 97%
- CAS Number:1090429-01-8
- Molecular formula:C12H16BrNO2S
- Molecular Weight:318.23
Yield:1090429-01-8 99%
Reaction Conditions:
with triethylamine in dichloromethane at 20;
Steps:
General procedure: A: Sulfonyl chloride (1 eq.) was dissolved in a mixture of dry DCM (0.2 M) and TEA (1.5 eq.). Amine (1.2 eq.) was added and the reaction was stirred at 20 °C until completion (TLC). The solvent was removed under reduced pressure and the crude product was purified by column flash-chromatography on silica to give the sulfonamide.
References:
Heinrich, Daniel M.;Flanagan, Jack U.;Jamieson, Stephen M.F.;Silva, Shevan;Rigoreau, Laurent J.M.;Trivier, Elisabeth;Raynham, Tony;Turnbull, Andrew P.;Denny, William A. [European Journal of Medicinal Chemistry,2013,vol. 62,p. 738 - 744] Location in patent:supporting information
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