1-[(2-chlorophenyl)methyl]-1H-pyrazole synthesis
2synthesis methods
- Product Name:1-[(2-chlorophenyl)methyl]-1H-pyrazole
- CAS Number:202344-35-2
- Molecular formula:C10H9ClN2
- Molecular Weight:192.64
Yield:202344-35-2 93%
Reaction Conditions:
Stage #1: NH-pyrazolewith sodium hydride in tetrahydrofuran;mineral oil at 20; for 0.5 h;
Stage #2: 1-bromomethyl-2-chlorobenzene in tetrahydrofuran;mineral oil at 20; for 12 h;
References:
Choi, Young Lok;Lee, Hyuk;Kim, Bum Tae;Choi, Kihang;Heo, Jung-Nyoung [Advanced Synthesis and Catalysis,2010,vol. 352,# 11-12,p. 2041 - 2049] Location in patent:supporting information; experimental part
