ChemicalBook CAS DataBase List 1-(2-Chlorophenyl)piperazine

1-(2-Chlorophenyl)piperazine synthesis

7synthesis methods

Product Name:1-(2-Chlorophenyl)piperazine
CAS Number:39512-50-0
Molecular formula:C10H13ClN2
Molecular Weight:196.68

110-85-0 Synthesis

110-85-0
552 suppliers
$5.00/5 g

348-51-6
212 suppliers
$21.00/5 g

39512-50-0
138 suppliers
$68.00/5g

Yield: 61%

Reaction Conditions:

with potassium carbonate in 1-methyl-pyrrolidin-2-one at 250; for 3 h;Sealed tube;Microwave irradiation;

Steps:

11 1-(2-Chlorophenyl)piperazine (12)
General procedure: Fluorobenzenes (3eq, 30 mmol), amines (1 eq, 10 mmol), K₂CO₃ (2 eq) and NMP (15 mL) were charged to a 20 mL microwave vial equipped with a magnetic stir bar. The vial was capped and heated in the Biotage Initiator microwave reactor (with following setting: prestir = 20 s; absorption level = very high; fixed hold time = on) for 1-6 h at 190-250 °C as indicated. After cooling to 50 °C, the vial was opened and the contents were transferred to a separatory funnel containing water (60 mL) and extracted with ethyl acetate (15 mL × 4). The combined organic extracts were washed with water, and dried over anhydrous Na₂SO₄. After removal of the solvent, the residues were purified by the column chromatography on silica gel to give the pure product.

References:

Meng, Xiangguo;Cai, Zhengyan;Xiao, Sa;Zhou, Weicheng [Journal of Fluorine Chemistry,2013,vol. 146,p. 70 - 75]

41202-32-8 Synthesis