ChemicalBook CAS DataBase List 1,2-Dimethyl-4-phenyl-1H-pyrrole

1,2-Dimethyl-4-phenyl-1H-pyrrole synthesis

8synthesis methods

Product Name:1,2-Dimethyl-4-phenyl-1H-pyrrole
CAS Number:52266-24-7
Molecular formula:C12H13N
Molecular Weight:171.24

1,5-Dimethyl-3-phenyl-1H-pyrrole-2,4-dicarboxylic acid

1192717-69-3
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52266-24-7
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Yield:52266-24-7 91%

Reaction Conditions:

with 2-aminoethan-1-ol at 175; for 1 h;Inert atmosphere;

Steps:

1.5 The fifth step: preparation of 1,2-dimethyl-4-phenyl-1H-pyrrole (A-6)

Compound A-5 (4.8 g, 18.5 mmol) and ethanolamine (13 mL) were added to the reaction flask, the reaction solution was replaced with nitrogen, and the reaction was carried out at 175° C. for 1 h. LC-MS showed that the reaction was complete.Water was added to the reaction system, extracted twice with ethyl acetate, the organic phases were combined, washed with saturated brine, and dried over anhydrous Na₂SO₄. After vacuum evaporation, the crude product was purified by silica gel column to obtain 2.9 g of white solid product A-6. Rate: 91%.

References:

WO2022/134837,2022,A1 Location in patent:Page/Page column 27; 29

94-02-0
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$14.00/5g

52266-24-7
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1H-Pyrrole-2,4-dicarboxylicacid, 5-methyl-3-phenyl-, 2,4-diethyl ester

3651-13-6
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52266-24-7
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References

Diethyl 1,5-diMethyl-3-phenyl-1H-pyrrole-2,4-dicarboxylate

161560-98-1
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52266-24-7
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References

Benzenepropanoic acid, a-(hydroxyimino)-b-oxo-, ethyl ester

60317-41-1
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52266-24-7
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References