1-(2-ethylphenyl)propan-1-ol synthesis
- Product Name:1-(2-ethylphenyl)propan-1-ol
- CAS Number:67541-89-3
- Molecular formula:C11H16O
- Molecular Weight:164.2441
1973-22-4
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67541-89-3
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$389.00/1g
Yield:67541-89-3 95%
Reaction Conditions:
Stage #1: 1-bromo-2-ethylbenzenewith iodine;magnesium in tetrahydrofuran at -5 - 5; for 2 h;
Stage #2: propionaldehyde in tetrahydrofuran at 20;
Steps:
1.1-3.1 Example 1
Take a 250ml three-necked flask, add 13g of 2-bromoethylbenzene, add 52g of tetrahydrofuran to dissolve, cool to -5~5, add magnesium chips, add 0.5g of elemental iodine, and initiate the reaction at -5~5 for 2 hours . The temperature was controlled at -5°C to 5°C, and 5.3 g of n-propanal was added dropwise. After the dropwise addition, the temperature was raised to room temperature for reaction. The reaction was monitored by HPLC until the reaction was complete, and the grating reagent 2-ethylbenzene magnesium bromide was obtained. The reaction solution was added dropwise to 100 g of ice water, and the extraction solvent was added for extraction. The organic layer was washed twice with water, allowed to stand for liquid separation, and the organic phase was concentrated under reduced pressure to obtain 1-(2-ethylphenyl)propanol with a purity of 98.0%. , The weight is 11g, and the yield is 95%.
References:
CN112390767,2021,A Location in patent:Paragraph 0021; 0024; 0027
16819-79-7
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67541-89-3
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$389.00/1g