1-(2-Hydroxy-5-fluorophenyl)ethanol synthesis
- Product Name:1-(2-Hydroxy-5-fluorophenyl)ethanol
- CAS Number:850793-83-8
- Molecular formula:C8H9FO2
- Molecular Weight:156.15
347-54-6
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$14.00/1g
75-16-1
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$12.00/10ml
850793-83-8
25 suppliers
$184.37/5g
Yield:850793-83-8 94%
Reaction Conditions:
in tetrahydrofuran;diethyl ether at -78 - 20; for 0.5 h;
Steps:
82.B
Step B MeMgBr (10 mL, 3 M solution in Et20) is added to a-78 °C cooled solution of aldehyde (2 g, 14.285 mmol) in THF (30 mL). The mixture is allowed to reach r. t. , stirred for 30 min. and poured into brine. It is acidified with diluted HCI and extracted with EtOAc. The organic layer is dried, filtered and concentrated, to give a crude residue that is purified by flash chromatography on Si02 (10-15% EtOAc/hexanes) to afford 2.1 g of the addition product (94%, colorless oil).
References:
WO2005/37763,2005,A1 Location in patent:Page/Page column 126
394-32-1
346 suppliers
$9.00/5g
850793-83-8
25 suppliers
$184.37/5g