ChemicalBook CAS DataBase List 1-(2-Methoxy-5-Morpholinophenyl)thiourea

1-(2-Methoxy-5-Morpholinophenyl)thiourea synthesis

5synthesis methods

Product Name:1-(2-Methoxy-5-Morpholinophenyl)thiourea
CAS Number:383870-59-5
Molecular formula:C12H17N3O2S
Molecular Weight:267.35

383870-86-8 Synthesis

N-(2-Methoxy-5-MorpholinophenylcarbaMothioyl)benzaMide

383870-86-8
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1-(2-Methoxy-5-Morpholinophenyl)thiourea

383870-59-5
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Yield:383870-59-5 97%

Reaction Conditions:

with sodium methylate in methanol at 0 - 20; for 4.5 h;

Steps:

1.d

212 g Benzoylthiourea (571 mmol) were suspended in 1270 ml methanol at RT, and 155 ml 30% methanolic sodium methoxide (861 mmol, 1.5 eq.) were added over 0.75 h. The suspension was stirred for 2.75 h, cooled to 0° C. and stirred for 1 h before being filtered. The crude product was sufficiently pure to be used directly in the next step. 148.7 g (97%).

References:

US2004/138465,2004,A1 Location in patent:Page/Page column 7

104-94-9 Synthesis