1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL synthesis
1synthesis methods
- Product Name:1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL
- CAS Number:25372-14-9
- Molecular formula:C10H10N2S
- Molecular Weight:190.26
Yield:25372-14-9 92.1%
Reaction Conditions:
Stage #1: 3-aminopropionaldehyde dimethyl acetal;2-tolyl isothiocyanate in methanol at 6 - 38; for 1 h;
Stage #2: with hydrogenchloride at 37 - 50; for 1 h;
References:
Matsugi;Fukuda;Muguruma;Yamaguchi;Minamikawa;Otsuka [Tetrahedron,2001,vol. 57,# 14,p. 2739 - 2744]