![](/CAS/GIF/78269-85-9.gif)
1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)& synthesis
- Product Name:1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&
- CAS Number:78269-85-9
- Molecular formula:C10H17NO5Si
- Molecular Weight:259.33
![N,N'-Disuccinimidyl carbonate](/CAS/GIF/74124-79-1.gif)
74124-79-1
460 suppliers
$5.00/5g
![2-(Trimethylsilyl)ethanol](/CAS/GIF/2916-68-9.gif)
2916-68-9
320 suppliers
$13.00/5g
![1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&](/CAS/GIF/78269-85-9.gif)
78269-85-9
116 suppliers
$32.00/1g
Yield:78269-85-9 84%
Reaction Conditions:
with triethylamine in acetonitrile at 20; for 3 h;
Steps:
Compound 41; TEA (21.9 mL, 155.6 mmol, 3.0 eq.) was added to 2-trimethylsilanyl- ethanol (7.4 mL, 51.88 mmol, 1.0 eq.) in 260 mL MeCN, followed by di- succinimidyl carbonate (20 g, 1.5 eq.). The reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated and extracted using EtOAc/ saturated NaHCO3. The organic layer was concentrated after dried over Na2SO4. Ether (100 mL) was added to the residue to form a precipitate. The precipitate was filtered and dried to give Compound 41 as a white solid (11.1 g, 84%). 1H NMR (300 MHz, CDCl3): δ 4.42 (t, 3 H), 2.82 (s, 4 H), 1.16 (t, 2 H), 0.1 (s, 9 H).
References:
GILEAD SCIENCES, INC. WO2008/11117, 2008, A2 Location in patent:Page/Page column 491
![N-Hydroxysuccinimide](/CAS/GIF/6066-82-6.gif)
6066-82-6
739 suppliers
$5.00/10g
![(2-[(CHLOROCARBONYL)OXY]ETHYL)TRIMETHYLSILANE](/CAS/20180601/GIF/20160-60-5.gif)
20160-60-5
17 suppliers
$50.00/5mg
![1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&](/CAS/GIF/78269-85-9.gif)
78269-85-9
116 suppliers
$32.00/1g
![2-(Trimethylsilyl)ethanol](/CAS/GIF/2916-68-9.gif)
2916-68-9
320 suppliers
$13.00/5g
![Triphosgene](/CAS/GIF/32315-10-9.gif)
32315-10-9
409 suppliers
$10.00/1g
![1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&](/CAS/GIF/78269-85-9.gif)
78269-85-9
116 suppliers
$32.00/1g
![2-(Trimethylsilyl)ethanol](/CAS/GIF/2916-68-9.gif)
2916-68-9
320 suppliers
$13.00/5g
![1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&](/CAS/GIF/78269-85-9.gif)
78269-85-9
116 suppliers
$32.00/1g