1-(3,4-DICHLOROPHENYL)-2-HYDROXY-1-ETHANONE synthesis

5synthesis methods

Product Name:1-(3,4-DICHLOROPHENYL)-2-HYDROXY-1-ETHANONE
CAS Number:113337-38-5
Molecular formula:C8H6Cl2O2
Molecular Weight:205.04

2632-10-2 Synthesis

2632-10-2
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$9.00/1g

1-(3,4-DICHLOROPHENYL)-2-HYDROXY-1-ETHANONE

113337-38-5
26 suppliers
$45.00/5mg

Yield:113337-38-5 42%

Reaction Conditions:

with sodium formate in methanol;

Steps:

R.23 Reference Example 23

Reference Example 23 A mixture of 2-bromo-3',4'-dichloroacetophenone (78.0 g), sodium formate (68.0 g) and methanol (300 ml) was stirred with heating under reflux for 16 hours. The reaction mixture was concentrated and poured into water (1 L). The solid precipitates were filtered, washed with water and then isopropyl ether, and air-dried. The residue was dried under reduced pressure to give crystals of 2-hydroxy-3',4'-dichloroacetophenone (25.0 g, 42%). Recrystallization from ethyl acetate-hexane gave pale yellow prisms. Melting point 115-118° C.

References:

US6605629,2003,B1

2642-63-9 Synthesis