ChemicalBook CAS DataBase List 1,3,4-Oxadiazole,2-(4-fluorophenyl)-(9CI)

1,3,4-Oxadiazole,2-(4-fluorophenyl)-(9CI) synthesis

10synthesis methods

Product Name:1,3,4-Oxadiazole,2-(4-fluorophenyl)-(9CI)
CAS Number:595567-05-8
Molecular formula:C8H5FN2O
Molecular Weight:164.14

456-06-4 Synthesis

456-06-4
147 suppliers
$7.00/1g

149-73-5 Synthesis

149-73-5
523 suppliers
$12.00/5g

1,3,4-Oxadiazole,2-(4-fluorophenyl)-(9CI)

595567-05-8
26 suppliers
$65.00/500mg

Yield:595567-05-8 95%

Reaction Conditions:

with Al³⁺-K₁₀ montmorillonite clay in neat (no solvent) at 55; for 0.25 h;Microwave irradiation;

Steps:

General procedure for 1,3,4-oxadiazole synthesis

General procedure: A 5 mL microwave vial was charged with acidhydrazide (100 mg, 1 eq), trimethyl orthoester (2 eq) and Al³⁺-K10 clay (75 mg). The resulting mixture was kept under microwave irradiation maintaining the temperature at 55 °C for 15 min (Microwave irradiations were performed on CEM-discover model No. 908010). The reaction was monitored by TLC. After completion of the reaction, reaction mixture was diluted with ethyl acetate stirred well, filtered, washed well with ethyl acetate. Filtrate was evaporated under reduced pressure to obtain highly pure product. In some cases, products were purified by column chromatography using 60-120 mesh silica with 20-100 % ethyl acetate in pet ether as eluting solvents. The catalyst recovered by filtration was reused for another 5 more times.

References:

Suresh, Dhanusu;Kanagaraj, Kuppusamy;Pitchumani, Kasi [Tetrahedron Letters,2014,vol. 55,# 27,p. 3678 - 3682] Location in patent:supporting information

456-06-4 Synthesis

456-06-4
147 suppliers
$7.00/1g