1-(3,5-DIFLUOROBENZYL)PIPERAZINE synthesis

Yield:868054-29-9 77%

Reaction Conditions:

in acetonitrile at 0 - 20; for 24 h;

Steps:

4.1.3. Procedure for the synthesis of compounds 7-12 (procedure A)

General procedure: To a solution of piperazine (4 equiv.) in acetonitrile a solution ofthe appropriate phenyl-alkyl-halide derivativewas added dropwiseat 0 °C. After the addition the reaction mixture was stirred at roomtemperature for 24 h. Concentration under reduced pressureresulted in solid residue. The crude product was purified by silicagel column chromatography in DCM/MeOH/25% NH3(aq) (9/1/0.1, v/v/v).

References:

Panek, Dawid;Wi?ckowska, Anna;Wichur, Tomasz;Bajda, Marek;Godyń, Justyna;Jończyk, Jakub;Mika, Kamil;Janockova, Jana;Soukup, Ondrej;Knez, Damijan;Korabecny, Jan;Gobec, Stanislav;Malawska, Barbara [European Journal of Medicinal Chemistry,2017,vol. 125,p. 676 - 695]