1-(3,5-difluoropyridin-2-yl)ethanone synthesis
- Product Name:1-(3,5-difluoropyridin-2-yl)ethanone
- CAS Number:1075756-90-9
- Molecular formula:C7H5F2NO
- Molecular Weight:157.12
298709-29-2
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75-16-1
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1075756-90-9
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Yield:-
Reaction Conditions:
Stage #1:3,5-difluoropyridine-2-carbonitrile;methylmagnesium bromide in tetrahydrofuran;diethyl ether at 0 - 20;
Stage #2: with sulfuric acid;water in tetrahydrofuran;diethyl ether; pH=4
Stage #3: with ammonia in tetrahydrofuran;diethyl ether;water
References:
ABBOTT GMBH & CO. KG WO2005/82871, 2005, A2 Location in patent:Page/Page column 96; 97