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1-(3 5-DIMETHOXYPHENYL)HEPTAN-1-ONE 96 synthesis

6synthesis methods
-

Yield:39192-51-3 90%

Reaction Conditions:

Stage #1: 1-bromo-hexanewith magnesium in tetrahydrofuran at 20; for 0.5 h;Metallation;
Stage #2: (3,5-dimethoxyphenyl)-N-methoxy-N-methylcarboxamide in tetrahydrofuran at 0; for 1.5 h;Further stages.;Grignard reaction;

References:

Harrington, Paul E.;Stergiades, Ioanna A.;Erickson, Joy;Makriyannis, Alexandros;Tius, Marcus A. [Journal of Organic Chemistry,2000,vol. 65,# 20,p. 6576 - 6582]