ChemicalBook CAS DataBase List 1,3,5-Trifluoro-2-nitrobenzene

1,3,5-Trifluoro-2-nitrobenzene synthesis

6synthesis methods

Product Name:1,3,5-Trifluoro-2-nitrobenzene
CAS Number:315-14-0
Molecular formula:C6H2F3NO2
Molecular Weight:177.08

372-38-3 Synthesis

372-38-3
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$9.00/1g

315-14-0
226 suppliers
$13.00/5g

Yield:315-14-0 47.74%

Reaction Conditions:

with sulfuric acid;nitric acid at 0; for 2 h;

Steps:

79 Synthesis of compound 79.1.

To a solution of 79 (5.0g, 37.87mmol, 1.5eq) in sulfuric acid (17mL) was added nitric acid (23mL) dropwise at 0°C. Reaction mixture was stirred at 0°C for 2h. After completion of reaction, reaction mixture was transferred to ice and product was extracted with ethyl acetate. Organic layer was combined, dried over sodium sulfate and concentrated under reduced pressure to obtain 79.1. (3.2g, Yield: 47.74%), MS (ES): m/z 178.01 [M+H] ⁺.

References:

WO2020/112937,2020,A1 Location in patent:Paragraph 00846