![](/CAS/GIF/938459-14-4.gif)
1-(3-aminophenyl)imidazolidin-2-one synthesis
- Product Name:1-(3-aminophenyl)imidazolidin-2-one
- CAS Number:938459-14-4
- Molecular formula:C9H11N3O
- Molecular Weight:177.2
![[3-(2-oxo-imidazolidin-1-yl)-phenyl]-carbamic acid tert-butyl ester](/CAS/20180528/GIF/1213702-26-1.gif)
1213702-26-1
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![1-(3-aminophenyl)imidazolidin-2-one](/CAS/GIF/938459-14-4.gif)
938459-14-4
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$98.00/1g
Yield:938459-14-4 96%
Reaction Conditions:
Stage #1: [3-(2-oxo-imidazolidin-1-yl)-phenyl]-carbamic acid tert-butyl esterwith trifluoroacetic acid in dichloromethane at 20; for 5 h;
Stage #2: with sodium carbonate in dichloromethane;
Steps:
1.iii
Hi) l-(3-Amino-phenyl)-imidazolidin-2-one; A solution of [3-(2-oxo-imidazolidin-l-yl)-phenyl]-carbamic acid tert-butyl ester (0.88 g, 3.2 mmol) and trifluoroacetic acid (2 ml) in dichloromethane (10 ml) were stirred at room temperature for 5 hours. The reaction was quenched with sodium carbonate (20 ml) and extracted with dichloromethane (3 x 50 ml). The combined organics were dried (magnesium sulphate) and concentrated in vacuo (0.54g, 96%). HPLC retention time 1 min. Mass spectrum (ES+) m/z 178 (M+H).
References:
WO2010/23446,2010,A1 Location in patent:Page/Page column 32