1-(3-BROMOPHENYL)-2-PROPANOL synthesis

3synthesis methods

Product Name:1-(3-BROMOPHENYL)-2-PROPANOL
CAS Number:1184574-05-7
Molecular formula:C9H11BrO
Molecular Weight:215.09

21906-32-1
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Yield:1184574-05-7 99%

Reaction Conditions:

with sodium tetrahydroborate;ethanol at 20;

Steps:

116.116a 116a) 1 -(3-Bromophenyl)propan-2-ol

116a) 1 -(3-Bromophenyl)propan-2-ol To a solution of 1 -(3-bromophenyl)propan-2-one (4.8 g, 22.53 mmol) in Ethanol (50 mL) was added sodium borohydride (1 .705 g, 45.1 mmol). The reaction mixture was stirred overnight at room temperature. Water was added and the mixture was extracted with ethyl acetate. The organic extract was washed with 30 mL of 1 .0 N HCI (aq) and water, dried over anhydrous magnesium sulfate. It was filtered and the filtrate was concentrated to give the title compound as clear colorless oil (4.8 g, 22.32 mmol, 99.0 % yield) used as intermediate without further purification. LC-MS m/z 237.9 (M+Na)⁺, 0.88 (ret. time).

References:

WO2017/60854,2017,A1 Location in patent:Page/Page column 358

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References

108-36-1
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References