ChemicalBook CAS DataBase List 1,3-DICHLORO-1,1-DIFLUOROPROPANE

1,3-DICHLORO-1,1-DIFLUOROPROPANE synthesis

9synthesis methods

Product Name:1,3-DICHLORO-1,1-DIFLUOROPROPANE
CAS Number:819-00-1
Molecular formula:C3H4Cl2F2
Molecular Weight:148.97

1070-78-6
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$8.00/25g

819-00-1
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inquiry

677-21-4
127 suppliers
$35.00/25g

Yield:677-21-4 91 %Chromat. ，819-00-1 9 %Chromat.

Reaction Conditions:

with hydrogen fluoride;activated by HF amorphous Zn/chromia catalyst at 200;

Steps:

5

Example 5: Hydrofluorination of 250fb (CCbCH₂CH₂CI) at elevated pressureThe reactor, made from an lnconnel tube 30 cm x 0.5 inches, was charged with 6g of a 5.2 % Zn/Chromia catalyst which was essentially amorphous in character, which was treated as follows:The catalyst was first dried by heating under nitrogen (80 ml/min) at 25O⁰C and 3 barg for 48 hours. Next, pre-fluorination of the catalyst was begun by introducing HF (4 ml/min) into the nitrogen stream and increasing the temperature to 300⁰C for 16 hours. During the last 5 hours the nitrogen flow was reduced steadily to zero. The temperature was then ramped to 38O⁰C at 25°C/hr and held at 38O⁰C for 7 hours and then cooled to 25O⁰C at 25°C/hr.A feed mixture comprising 250fb (3 ml/min) and HF (45 ml/min) was then passed over the catalyst at 15 barg and 200⁰C. The gases exiting the reactor were periodically sampled and analysed by GC after passing through an alkaline scrubber to remove acid gases. The only products detected in the reactor off-gases following following removal of the acid gases were the desired product 1243zf (91 mol %, CF₃CH=CH₂) and 1 ,1- difluoro-1,3-dichloropropane (9 mol %, CF₂CICH₂CH₂CI).It is believed that the 1 ,1-difluoro-1,3-dichloropropane could be converted to 1243zf by altering the reaction conditions (e.g. by increasing the temperature and/or contact time). In this way, 250fb could be fully converted in 100% selectivity to 1243zf in a single pass.