ChemicalBook CAS DataBase List 1,3-Dicyclohexyl-1,3-propanedione

1,3-Dicyclohexyl-1,3-propanedione synthesis

6synthesis methods

Product Name:1,3-Dicyclohexyl-1,3-propanedione
CAS Number:55846-67-8
Molecular formula:C15H24O2
Molecular Weight:236.35

3289-28-9 Synthesis

3289-28-9
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55846-67-8
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Yield:55846-67-8 45%

Reaction Conditions:

with sodium hydride in N,N-dimethyl-formamide at 0 - 20; for 12 h;

Steps:

1

After dissolving 102.41g (655.54mmol) of Intermediate 22-13 and 82.73g (655.54mmol) of Intermediate 22-14 in 1L of DMF, an ice bath was installed to maintain 0 and NaH (60%) 26.22g (655.54mmol) was added dropwise. I did. After raising the temperature to room temperature and stirring for 12 hours, after confirming the reaction, 1L of 1N HCl was added and stirred. After extraction by adding 1 L of PE, distillation and column to give 69.72 g of intermediate 22-15 in a yield of 45%.

References:

KR2020/108161,2020,A Location in patent:Paragraph 0099; 0135-0138