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947279-21-2

1,3-Difluoro-2-(phenylmethoxy)benzene synthesis

2synthesis methods
-

Yield:947279-21-2 98%

Reaction Conditions:

Stage #1: 2,6-difluorophenolwith potassium carbonate in acetone at 70; for 1 h;Sealed tube;
Stage #2: benzyl bromide in acetone at 20 - 70; for 17 h;Sealed tube;

References:

Lassalas, Pierrik;Gay, Bryant;Lasfargeas, Caroline;James, Michael J.;Tran, Van;Vijayendran, Krishna G.;Brunden, Kurt R.;Kozlowski, Marisa C.;Thomas, Craig J.;Smith, Amos B.;Huryn, Donna M.;Ballatore, Carlo [Journal of Medicinal Chemistry,2016,vol. 59,# 7,p. 3183 - 3203]