ChemicalBook CAS DataBase List 1,3-dihydro-3-ethyl-2H-indol-2-one

1,3-dihydro-3-ethyl-2H-indol-2-one synthesis

13synthesis methods

Product Name:1,3-dihydro-3-ethyl-2H-indol-2-one
CAS Number:15379-45-0
Molecular formula:C10H11NO
Molecular Weight:161.2

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Yield:15379-45-0 77%

Reaction Conditions:

with D-glucose in water at 40; for 48 h;

Steps:

4.6 General procedure for the baker's yeast reduction of olefins

General procedure: To a mixture of commercial fresh or freeze-dried baker's yeast (Sigma) (7.5 g) in tap water (50 mL) at 40°C, d-glucose (0.75 g, 4.17 mmol) was added. The substrate (100 mg) was added and the flask was placed for 2 d in a termo-shaker. The mixture was then filtered on a celite pad and washed twice with water (50 mL) and once with EtOAc (50 mL). The aqueous was extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na₂SO₄) and the solvent was removed under reduced pressure. The crude residue was purified by silica gel column chromatography eluting with 4:6 EtOAc/hexane to give the product.

References:

Rossetti, Arianna;Sacchetti, Alessandro;Bonfanti, Marta;Roda, Gabriella;Rainoldi, Giulia;Silvani, Alessandra [Tetrahedron,2017,vol. 73,# 31,p. 4584 - 4590]

59-48-3 Synthesis