1,3-Dimethylbarbituric acid synthesis
- Product Name:1,3-Dimethylbarbituric acid
- CAS Number:769-42-6
- Molecular formula:C6H8N2O3
- Molecular Weight:156.14
3158-63-2
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Yield:769-42-6 80%
Reaction Conditions:
with trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane;water;potassium hydroxide in acetonitrile at 20; for 0.25 h;
Steps:
4.2. Typical procedure for desulfurization of thiourea derivatives 1a-1s to oxoanalogs 2a-2s
To a stirred solution of phenylthiourea 1 (1mmol) and 5% aq. KOH (5 mL) in acetonitrile (5 mL) was added DHPDMDO (0.332 g, 2mmol). The resulting mixture was allowed to stir at room temperature for an appropriate time (Table 2). After completion of the reaction as monitored by TLC, the reaction mixture was diluted with water (10mL) and the product was extracted in dichloromethan (3×5mL). The combined organic layer was washed with water (2×5mL) and dried over anhydrous Na2SO4. Evaporation of the solvent under reduced pressure gave almost pure products. Structures of the known products were established on the basis of their physical and spectroscopic (IR, 1H-NMR and 13C-NMR) data, which were consistent with those reported.[34,61]
References:
Azarifar, Davood;Golbaghi, Maryam [Journal of Sulfur Chemistry,2016,vol. 37,# 1,p. 1 - 13]
4097-20-5
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21544-73-0
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