ChemicalBook CAS DataBase List 1,3-Dioxo-2-isoindolineaceticacid

1,3-Dioxo-2-isoindolineaceticacid synthesis

6synthesis methods

Product Name:1,3-Dioxo-2-isoindolineaceticacid
CAS Number:6296-53-3
Molecular formula:C10H7NO4
Molecular Weight:205.17

603-11-2 Synthesis

603-11-2
612 suppliers
$15.00/25 g

108-24-7
5 suppliers
$14.00/250ML

6296-53-3
299 suppliers
$6.00/250mg

Yield:6296-53-3 83%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen at 80 - 115; under 7500.75 Torr;Autoclave;Temperature;

Steps:

6 Preparation of 3-acetylamino phthalic anhydride
2-nitrophthalic acid (100. 0 g), acetic anhydride (1 L) was added to a hydrogenation kettle, heated to 80 ° C,After the raw material disappeared, the mixture was cooled to room temperature, 10% Pd / C (3 g) was added, replaced with nitrogen twice, hydrogen was introduced to IMPa,The reaction is maintained at room temperature until no hydrogen is absorbed, vented, blown with nitrogen,Heated to 110-115 ° C reaction to the raw material or intermediate state disappeared,Hot filter, cooled to 0-5 ° C, filtered, washed with glacial acetic acid to give pale yellow crystals, dried 80. 6g, yield 83%, HPLC 99. 0%.

References:

Shanghai UTOpharm Company Limited;Luo, junzhi;Zeng, YuPing CN105294534, 2016, A Location in patent:Paragraph 0036; 0037

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