1,3-Dithiane,2-(1-methylethyl)-(9CI) synthesis
- Product Name:1,3-Dithiane,2-(1-methylethyl)-(9CI)
- CAS Number:6007-25-6
- Molecular formula:C7H14S2
- Molecular Weight:162.32
Yield:6007-25-6 100%
Reaction Conditions:
with boron trifluoride diethyl ether complex in dichloromethane at 0 - 20; for 1 h;
Steps:
28.A
To a mixture of isobutyraldehyde (9.1 mL, 100 mmol) and 1,3-propanedithiol (10 mL, 100 mmol) in dichloromethane at 0° C. was added boron trifluoride diethyl etherate (6.4 mL, 50 mmol). The resulting mixture was stirred at 0° C. for 30 min and at room temperature for 30 min. The reaction mixture was washed with brine, 5% NaHCO3, and brine again. The organic phase was separated and dried over Na2SO4, then concentrated to give 16 g (100%) of the title compound as a yellow liquid. This was carried to the next step without further purification. 1H NMR (CDCl3, 400 MHz): δ 1.057 (d, J=7.2 Hz, 3H), 1.059 (d, J=7.2 Hz, 3H), 1.80 (m, 1H), 1.97-2.08 (m, 2H), 2.82 (m, 4H), 4.00 (d, J=5.2 Hz, 1H).
References:
US2006/229361,2006,A1 Location in patent:Page/Page column 42
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