1-(3-FLUORO-4-PIPERAZIN-1-YLPHENYL)ETHANONE synthesis
- Product Name:1-(3-FLUORO-4-PIPERAZIN-1-YLPHENYL)ETHANONE
- CAS Number:189763-57-3
- Molecular formula:C12H15FN2O
- Molecular Weight:222.26
Yield: 98%
Reaction Conditions:
in acetonitrile for 15 h;Reflux;
Steps:
2-2 1- (3-Fluoro-4- (piperazine-1-yl) phenyl) ethane-1-one
In a 50 mL two-necked round bottom flask,1- (3,4-difluorophenyl) ethane-1-one (334 mg, 2.1 mmol),Piperazine (701 mg, 8.3 mmol)And MeCN (4.7 mL) were added. After refluxing for 15 hoursPour the mixture into water,Extracted with EtOAc.Water the organic layer,Wash with brine,Then it was dried with Na2SO4. After filtrationRemove the solvent by evaporation1- (3-Fluoro-4- (piperazine-1-yl) phenyl) ethane-1-one was obtained as a yellow solid (460 mg, 98%).
References:
Tokai National Higher Education Organization;Tetsuya, Higashiyama;Kumi, Tokida;Kenichiro, Itami;Ayaka, Ueda;Hiroyuki, Kitano;Hideto, Ito;Ayato, Sato JP2020/147524, 2020, A Location in patent:Paragraph 0156-0158
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