1-(3-fluorophenyl)-1H-pyrazole-4-carboxylic acid synthesis
- Product Name:1-(3-fluorophenyl)-1H-pyrazole-4-carboxylic acid
- CAS Number:138907-82-1
- Molecular formula:C10H7FN2O2
- Molecular Weight:206.17
138907-70-7
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138907-82-1
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Yield:138907-82-1 88%
Reaction Conditions:
Stage #1: ethyl 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylatewith Isovaleronitrile in tetrahydrofuran;Reflux;
Stage #2: with methanol;lithium hydroxide in tetrahydrofuran;
References:
WO2014/41007,2014,A1 Location in patent:Page/Page column 19-20
936940-82-8
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138907-82-1
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$203.00/100mg
2924-16-5
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138907-82-1
19 suppliers
$203.00/100mg