1-(3-IODOPHENYL)CYCLOPROPANECARBONITRILE synthesis

Yield:124276-77-3 75%

Reaction Conditions:

with N-benzyl-N,N,N-triethylammonium chloride;sodium hydroxide in water at 20;

Steps:

a Step a

The 3-iodobenzene acetonitrile s2-1 (365mg, 1.5mmol),1,2-Dibromoethane (845mg, 4.5mmol) and benzyltriethylammonium chloride (TEBAC) (15mg, 0.066mmol) were added to 50% aqueous sodium hydroxide solution (20mL) successively,Stir at room temperature overnight. After TLC monitors that the reaction is complete, pour into ice water and extract twice with dichloromethane (20 mL).The organic phases were combined, washed again with saturated brine, dried over anhydrous sodium sulfate, concentrated in vacuo, and separated and purified by column chromatography (petroleum ether/ethyl acetate: 100/1) to obtain a light yellow product s2-2 303mg (yield 75 %)

References:

CN112142711,2020,A Location in patent:Paragraph 0412-0414