1-(3-METHYLPHENYL)-1H-PYRROLE-2,5-DIONE synthesis

5synthesis methods

Product Name:1-(3-METHYLPHENYL)-1H-PYRROLE-2,5-DIONE
CAS Number:20299-79-0
Molecular formula:C11H9NO2
Molecular Weight:187.19

108-31-6 Synthesis

108-31-6
838 suppliers
$13.47/50g

108-44-1 Synthesis

108-44-1
366 suppliers
$9.00/1g

20299-79-0
28 suppliers
$109.00/500mg

Yield:20299-79-0 48%

Reaction Conditions:

with acetic acid for 18 h;Reflux;

Steps:

8

Maleic anhydride (25 g, 250 mmol) and 380 ml of acetic acid were added to a 500 mL single-necked bottle, and then m-toluidine (26.75 g, 250 mmol) was slowly added dropwise to the reaction solution with stirring at room temperature. After the dropwise addition, the reaction solution was placed in an oil bath and refluxed for 18 hours. After the reaction was completed, the reaction solution was cooled to room temperature, spin-dried the solvent, 100-200 mesh silica gel column chromatography, and a mixed solvent (3: 1) of petroleum ether and ethyl acetate was rinsed. 22.54 g of the compound represented by the structure of formula IVb was isolated with a yield of 48%.

References:

CN111018866,2020,A Location in patent:Paragraph 0145; 0152; 0153