1-(3-NITROPHENYL)-1H-IMIDAZOLE synthesis
- Product Name:1-(3-NITROPHENYL)-1H-IMIDAZOLE
- CAS Number:23309-09-3
- Molecular formula:C9H7N3O2
- Molecular Weight:189.17
Yield: 95%
Reaction Conditions:
with polystrene supported copper furfural catalyst in methanol at 40; for 12 h;Inert atmosphere;
Steps:
General procedure for N-arylation of N-H heterocycles witharylboronic acids
General procedure: In a 100 mL round bottom flask, Cu-grafted catalyst (0.05 g), aryl-boronic acid (1 mmol), N-H heterocycles (1.2 mmol), and 10 mLmethanol were stirred under nitrogen atmosphere, at 40C. Thereaction mixtures were collected at different time interval and identified by GC-MS and quantified by GC analysis. After the com-pletion of the reaction, the catalyst was filtered off and washedwith water followed by acetone and dried in oven. The filtrate wasextracted with ethyl acetate (3 × 20 mL) and the combined organiclayers were dried with anhydrous Na2SO4by vacuum. The filtratewas concentrated by vacuum and the resulting residue was puri-fied by column chromatography on silica gel to provide the desiredproduct.
References:
Islam, Sk.Manirul;Salam, Noor;Mondal, Paramita;Roy, Anupam Singha;Ghosh, Kajari;Tuhina [Journal of Molecular Catalysis A: Chemical,2014,vol. 387,p. 7 - 19]
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