1(3H)-Isobenzofuranone, 4-amino-6-chloro- synthesis
- Product Name:1(3H)-Isobenzofuranone, 4-amino-6-chloro-
- CAS Number:1207455-27-3
- Molecular formula:C8H6ClNO2
- Molecular Weight:183.59
1207455-26-2
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1207455-27-3
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Yield:1207455-27-3 90%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethyl acetate at 25; under 760.051 Torr; for 12 h;
Steps:
122E
A suspension of 6-chloro-4-nitroisobenzofuran-1(3H)-one (5 g, 23.5 mmol) and Pd/C (10%, 500 mg) in EtOAc (250 mL) was stirred at 25° C. under 1 atm of hydrogen for 12 hr. The mixture was filtered, and the cake was washed with EtOAc (100 mL×3). The filtrate was concentrated to give the title compound (3.87 g, yield 90%) as a white solid. LC-MS (ESI) m/z: 184 (M+1)+
References:
US2010/35883,2010,A1 Location in patent:Page/Page column 90
7499-06-1
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$5.00/1g
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154257-81-5
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$26.00/100mg
1207455-27-3
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294190-17-3
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$45.00/50mg
1207455-27-3
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1207455-25-1
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1207455-27-3
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