1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone synthesis
- Product Name:1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone
- CAS Number:3245-49-6
- Molecular formula:C12H15BrO3
- Molecular Weight:287.15
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Yield:-
Reaction Conditions:
with tetrabutylammomium bromide;potassium carbonate in acetonitrile at 80;Industry scale;
Steps:
1
Example 1: Preparation of l-[4-(3-chloro/bromo propoxy)-3-methoxyphenyl] ethanone (III)Acetonitrile (1L) was charged to 4-hydroxy-3-methoxy acetophenone (IV) (0.5 kg, 3.009 moles). l-Bromo-3-chloropropane (V) (1.89 Kg, 12.036 moles) was added to the reaction mixture and was stirred followed by addition of TBAB (0.030 Kg, 0.0903 moles ). Potassium carbonate (0.78 Kg, 5.657 moles) was added to the reaction mixture and heated to 80°C The mixture was cooled and filtered. The solid obtained was charged to dichloromethane (2 liters) and stirred. The reaction mixture was heated to 40-45 °C and distilled. The reaction mixture was cooled and methanol (0.5 liters ) was added followed by the addition of water (5 liters). The entire reaction mixture was added to chilled water and stirred. The reaction mixture was filtered and washed with water and dried. Yield: 0.779 Kg.Purity: 99.35%
References:
WO2012/164516,2012,A1 Location in patent:Page/Page column 4-5
