1-[4-(4-BENZYL-PIPERAZIN-1-YL)-PHENYL]-ETHANONE synthesis

5synthesis methods

Product Name:1-[4-(4-BENZYL-PIPERAZIN-1-YL)-PHENYL]-ETHANONE
CAS Number:163733-55-9
Molecular formula:C19H22N2O
Molecular Weight:294.39

100-52-7 Synthesis

100-52-7
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51639-48-6 Synthesis

51639-48-6
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1-[4-(4-BENZYL-PIPERAZIN-1-YL)-PHENYL]-ETHANONE

163733-55-9
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Yield:163733-55-9 54%

Reaction Conditions:

with sodium tris(acetoxy)borohydride in ethyl acetate at 20;

Steps:

38.A

Example 38: (E)-3-(5-{(E)-3-[4-(4-BenzyI-piperazin-1-yI)-phenyl]-3-oxo- propenyl}-pyridin-2-yl)-N-hydroxy-acrylamide; STEP A; A mixture of 1-(4-piperazin-1-yl-phenyl)-ethanone (500 mg, 2.45 mmol), benzaldehyde (312 mg, 2.94 mmol) and NaBH(OAc)₃ (778 mg, 3.67 mmol) in AcOEt (15 ml) was stirred at room temperature overnight. The resulting solution was partitioned between water and DCM and the organic phase was dried over Na₂SO₄ and evaporated in vacuo. The crude product was purified by silica gel chromatography (eluent: DCM/MeOH/NH₄OH 95:5:0.2) to give 390 mg of 1-[4-(4- benzyl-piperazin-1 -yl)-phenyl]-ethanone. Y= 54%

References:

WO2007/113249,2007,A2 Location in patent:Page/Page column 79-80