ChemicalBook CAS DataBase List 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE

1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE synthesis

5synthesis methods

Product Name:1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE
CAS Number:4101-32-0
Molecular formula:C10H11NO5
Molecular Weight:225.2

1131-62-0
317 suppliers
$14.00/5g

1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE

4101-32-0
114 suppliers
$22.39/1G

Yield: 89.4%

Reaction Conditions:

with nitric acid in dichloromethane at -10; for 2 h;

Steps:

1.2. General procedure for preparation of(1)
A mixture of 3,4-dimethoxyacetophenone (100.0 g, 0.6 mol) in CH₂Cl₂(500 mL, 5 v/w) was stirred at -10^oC.98% HNO₃(70 mL) was added slowly dropwise and then was stirred for 2 h. The reaction solution was poured into ice water with vigorous stirring, and the aqueous phase was extracted with dichloromethane, washed with water, dried over Na₂SO₄and then concentrated under reduced pressure to give compound1as a yellow solid in 89.4% yield.

References:

Xu, Qiaoling;Dai, Baozhu;Li, Zhiwei;Xu, Le;Yang, Di;Gong, Ping;Hou, Yunlei;Liu, Yajing [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 19,art. no. 126630] Location in patent:supporting information