ChemicalBook CAS DataBase List 1,4,6-Triazaindene

1,4,6-Triazaindene synthesis

4synthesis methods

Product Name:1,4,6-Triazaindene
CAS Number:272-50-4
Molecular formula:C6H5N3
Molecular Weight:119.12

2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE

63200-54-4
250 suppliers
$18.00/1g

1119280-66-8
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$57.00/100mg

272-50-4
84 suppliers
$66.00/100mg

Yield: 61%

Reaction Conditions:

with hydrogen;sodium hydrogencarbonate;palladium 10% on activated carbon in ethanol at 20; for 3 h;

Steps:

To a solution of 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (6.6 g, 35.3 mmol) in ethanol (200 mL) was added sodium hydrogen carbonate (2.96 g) and Palladium on carbon (10%, 0.66 g). The mixture was stirred under an atmosphere of hydrogen at room temperature for 3 h. The mixture was filtered then filtrate absorbed onto silica gel. Flash chromatography, eluting with chloroform/methanol 4/1, afforded 2-chloro-5H- pyrrolo[3,2-d]pyrimidine (3.3 g, 61%). Also recovered from the column was 5H- pyrrolo[3,2-d]pyrimidine (1.5 g)

References:

CYTOPIA RESEARCH PTY LTD WO2009/62258, 2009, A1 Location in patent:Page/Page column 99