1-(4-Amino-2,5-dichloro-phenyl)-acetic acid synthesis

Yield:792916-43-9 95%

Reaction Conditions:

with hydrogen;3percent Pt-S-carbon in ethanol at 20; for 5 h;Product distribution / selectivity;

Steps:

4 (2,5-Dichloro-4-aminophenyl)acetic acid

Example 4 (2,5-Dichloro-4-aminophenyl)acetic acid Ethanol (7 mL) and 3% Pt-S-carbon (50% Wet, 150 mg) were added to (2,5-dichloro-4-nitrophenyl)acetic acid (1.0 g), and the mixture was stirred for 5 hours under hydrogen flow at room temperature. After completion of reaction had been confirmed through HPLC, the reaction mixture was subjected to filtration, and the solvent was removed under reduced pressure, to thereby yield the title compound (0.84 g, 95%) as a yellowish brown solid. ¹H-NMR(DMSO-d6, 400MHz)δ: 3.51(s,2H,Ph-CH2-), 5.53(s,1H,NH2), 6.84(s,1H,Ph), 7.23(s,1H,Ph), 12.33(br,1H,OH)

References:

EP1698611,2006,A1 Location in patent:Page/Page column 33