1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine synthesis
- Product Name:1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine
- CAS Number:334981-10-1
- Molecular formula:C11H16N2O2S
- Molecular Weight:240.32
![1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine](/CAS/GIF/340041-91-0.gif)
340041-91-0
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$170.00/1g
334981-10-1
177 suppliers
$21.00/1g
Yield:334981-10-1 90.21%
Reaction Conditions:
with 5%-palladium/activated carbon;hydrogen in ethanol; under 3040.2 Torr; for 2 h;Reagent/catalyst;Solvent;
Steps:
2.3 Step 3: Preparation of 1-(4-aminophenylmethylsulfonyl)pyrrolidine:
26.5 g of the product of the second step of 1-(4-nitrophenylmethylsulfonyl)pyrrolidine (0.1 mol) was dissolved in 20 ml of ethanol, 5% palladium on carbon was added, and hydrogen was reacted at 4 atm, reaction 2 hours. The palladium carbon was removed by filtration to adjust the pH to 3-4. After extraction, the aqueous layer was extracted twice with ethyl acetate, and then the aqueous layer was adjusted to pH 13 again, and ethyl acetate was extracted 2-3 times. The combined organic phases were dried over anhydrous sodium sulfate and evaporated under reduced pressure, to give 21.65 g as a white solid, a yield of 90.21%.
References:
CN108440452,2018,A Location in patent:Paragraph 0042; 0047-0049; 0054-0056; 0061-0063; 0068-0070
4025-75-6
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334981-10-1
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53992-33-9
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334981-10-1
177 suppliers
$21.00/1g