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17764-92-0

1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE synthesis

3synthesis methods
Preparation by Friedel–Crafts acylation of m-bromophenol with propionyl chloride in the presence of aluminium chloride in refluxing ethylene dichloride for 2 h (78%)
Also obtained by Fries rearrangement of 3-bromophenyl propionate in the presence of aluminium chloride at 50° for 3 h (47%).
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Yield:17764-92-0 78%

Reaction Conditions:

with aluminium trichloride in 1,2-dichloro-ethane; for 2 h;Heating;

References:

Caron, Stéphane;Vazquez, Enrique [Synthesis,1999,# 4,p. 588 - 592]

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