1-(4-BroMophenyl)-2-propanol synthesis

6synthesis methods

Product Name:1-(4-BroMophenyl)-2-propanol
CAS Number:6186-23-8
Molecular formula:C9H11BrO
Molecular Weight:215.09

6186-22-7
148 suppliers
$75.00/25g

6186-23-8
11 suppliers
$140.00/25mg

Yield:6186-23-8 95%

Reaction Conditions:

with methanol;sodium tetrahydroborate at 0 - 20; for 3 h;

Steps:

1 Step 1: 1-(4-bromophenyl) propan-2-ol.

To a stirred solution of 1-(4- bromophenyl) propan-2-one (30.0 g, 140.8 mmol) in MeOH (150 mL) was added NaBH₄(13.3 g, 351.9 mmol) at 0 °C. The reaction mixture was stirred at rt for 3h. The reaction mixture was poured into H2O (500 mL) and extracted with EtOAc (3x200 mL). The combined organics were dried over Na₂SO₄, filtered and concentrated under reduced pressure to afford the title compound (29.0 g, 95%) as a colorless oil. 1H NMR (DMSO-d₆, 400 MHz): d 7.43 (d, 2H), 7.15 (d, 2H), 4.58 (d, 1H), 3.82-3.73 (m, 1H), 2.64-2.48 (m, 2H), 1.01 (d, 3H).

References:

WO2020/150372,2020,A1 Location in patent:Paragraph 00433; 00672

4489-23-0 Synthesis