1-(4-BROMOPHENYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE synthesis
- Product Name:1-(4-BROMOPHENYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE
- CAS Number:73387-60-7
- Molecular formula:C11H12BrNO
- Molecular Weight:254.12
99-90-1
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Yield:73387-60-7 95%
Reaction Conditions:
in 5,5-dimethyl-1,3-cyclohexadiene at 140; for 12 h;
Steps:
3.1 example 3 (1) Step one:
In a 100 mL dry round bottom flask,1.8 g (9 mmol) of p-bromoacetophenone and 3.9 mL (30 mmol) of N,N-dimethylformamide dimethyl acetal were respectively added as 30 mL of xylene as a solvent.The mixture was refluxed at 140 ° C for 12 hours.After the TLC detection reaction was completed, the heating was stopped, and the solvent was removed under reduced pressure.The crude product was purified by flash column chromatography to give a pale yellow solid N, N- (dimethylamino) -1- (4-bromophenyl) enaminone 2.15g (95% yield).
References:
CN108383763,2018,A Location in patent:Paragraph 0054; 0056
99-90-1
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20353-93-9
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73387-60-7
24 suppliers
$30.50/10g