1-(4-Bromophenyl)-4-propoxybenzene synthesis

Yield:154020-02-7 97.8%

Reaction Conditions:

with potassium carbonate in butanone; for 8 h;Reflux;

Steps:

General procedure: A suspension of 4-bromo-4'-hydroxybiphenyl (13) (3.5 g, 14.11 mmol), 1-bromoheptane (3.75 g, 21.05 mmol) and K₂CO₃ (4.9 g, 35.28 mmol) in 2-butanone (25 mL) was refluxed for 8 h. After cooling, the reaction mixture was diluted by CH₂Cl₂ (50 mL). After filtration, the organic layer was washed by H₂O (50 mL) and saturated brine (50 mL), dried over anhydrous Na₂SO₄, and filtrated. The solvent was condensed to 15 mL under reduced pressure, and the residue was collected and washed by cool hexane (0 °C) to afford 14c (4.6 g, yield 94.3%) as white solid.

References:

Yao, Jianzhong;Liu, Hongming;Zhou, Ting;Chen, Hai;Miao, Zhenyuan;Sheng, Chunquan;Zhang, Wannian [European Journal of Medicinal Chemistry,2012,vol. 50,p. 196 - 208] Location in patent:supporting information; experimental part